Efficacy and safety studies of a recombinant chimeric respiratory syncytial virus FG glycoprotein vaccine in cotton rats

被引：28

作者：

Prince, GA

Capiau, C

Deschamps, M

Fabry, L

Garçon, N

Gheysen, D

Prieels, JP

Thiry, G

Van Opstal, O

Porter, DD

机构：

[1] Vir Syst Inc, Rockville, MD 20850 USA

[2] SmithKline Beecham Biol, B-1330 Rixensart, Belgium

[3] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 22期

关键词：

D O I：

10.1128/JVI.74.22.10287-10292.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several formulations of a recombinant chimeric respiratory syncytial virus (RSV) vaccine consisting of the extramembrane domains of the F and G glycoproteins (FG) were tested in cotton rats to evaluate efficacy and safety. The FG vaccine was highly immunogenic, providing nearly complete resistance to pulmonary infection at doses as low as 25 ng in spite of inducing relatively low levels of serum neutralizing antibody at low vaccine doses. Upon RSV challenge animals primed,vith FG vaccine showed quite mild alveolitis and interstitial pneumonitis, which were eliminated by the addition of monophosphoryl lipid A to the formulation.

引用

收藏

页码：10287 / 10292

页数：6

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