ACE1 polymorphism and progression of SARS

被引：83

作者：

Itoyama, S

Keicho, N

Quy, T

Phi, NC

Long, HT

Ha, LD

Van Ban, V

Ohashi, J

Hijikata, M

Matsushita, I

Kawana, A

Yanai, H

Kirikae, T

Kuratsuji, T

Sasazuki, T

机构：

[1] Hanoi French Hosp, Hanoi, Vietnam

[2] Univ Tokyo, Grad Sch Med, Dept Human Genet, Tokyo, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 323卷 / 03期

关键词：

angiotensin converting enzyme; severe acute respiratory syndrome; association study; hypoxemia; polymorphism;

D O I：

10.1016/j.bbrc.2004.08.208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p = 0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1124 / 1129

页数：6

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