In-vitro activity of cephalosporins alone and combined with sulbactam against various strains of Acinetobacter baumannii with different antibiotic resistance profiles

被引：16

作者：

Aubert, G ^{[1
]}

Guichard, D ^{[1
]}

Vedel, G ^{[1
]}

机构：

[1] CHU COCHIN, DEPT BACTERIOL, PARIS, FRANCE

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1996年 / 37卷 / 01期

关键词：

D O I：

10.1093/jac/37.1.155

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The beta-lactamases of six strains of Acinetobacter baumannii were investigated using analytical isoelectric focusing, and the MIC values for 16 beta-lactam antibiotics determined against the strains. Three strains produced a chromosomal cephalosporinase (pI > 8.5), one strain a CARB-5 beta-lactamase (pI = 6.35), one strain a TEM-1 penicillinase (pI = 5.4) as well as a cephalosporinase (pI > 8.5), and one carbapenem-resistant strain a beta-lactamase with a pI > 8.5. Ceftazidime, cefepime, cefpirome, imipenem and meropenem were found to be the most effective beta-lactams against five strains. Sulbactam was active against four of the strains at 1-4 mg/L and showed enhanced killing effects with cefpirome.

引用

页码：155 / 160

页数：6

共 10 条

[1]

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[2]

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