Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents

被引:27
作者
Dear, James W.
Kobayashi, Hisataka
Brechbiel, Martin W.
Star, Robert A.
机构
[1] NIDDK, Renal Diagnost & Therapeut Unit, Bethesda, MD 20892 USA
[2] NCI, Mol Imaging Program, Ctr Canc Res, Bethesda, MD 20892 USA
[3] NCI, NIH, Radioimmune & Inorgan Chem Sect, Radiat Oncol Branch,Ctr Canc Res, Bethesda, MD 20892 USA
来源
NEPHRON CLINICAL PRACTICE | 2006年 / 103卷 / 02期
关键词
MRI; kidney; imaging; acute renal failure; sepsis; biomarker;
D O I
10.1159/000090608
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Acute renal failure (ARF) induced by sepsis has a high mortality but lacks effective treatments. To develop novel therapies we must diagnose renal injury early and accurately in septic patients and identify any additional insults such as nephrotoxic drugs and ischemia. In this short review we describe our experience using MRI with dendrimer-based contrast agents in mouse models of ARF. This technique can diagnose early renal injury before serum creatinine is elevated, distinguish different ARF etiologies, track drug therapy and predict outcome. As an ARF biomarker, MRI with dendrimer-based contrast is a promising technique deserving further development.
引用
收藏
页码:C45 / C49
页数:5
相关论文
共 23 条
[1]   alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats [J].
Chiao, H ;
Kohda, Y ;
McLeroy, P ;
Craig, L ;
Housini, I ;
Star, RA .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (06) :1165-1172
[2]   DYNAMIC GD-DTPA - ENHANCED MR IMAGING OF THE KIDNEY - EXPERIMENTAL RESULTS [J].
CHOYKE, PL ;
FRANK, JA ;
GIRTON, ME ;
INSCOE, SW ;
CARVLIN, MJ ;
BLACK, JL ;
AUSTIN, HA ;
DWYER, AJ .
RADIOLOGY, 1989, 170 (03) :713-720
[3]   Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice [J].
Dear, JW ;
Kobayashi, H ;
Jo, SK ;
Holly, MK ;
Hu, XZ ;
Yuen, PST ;
Brechbiel, MW ;
Star, RA .
KIDNEY INTERNATIONAL, 2005, 67 (06) :2159-2167
[4]   Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury [J].
Deng, JP ;
Kohda, Y ;
Chiao, H ;
Wang, YQ ;
Hu, XH ;
Hewitt, SM ;
Miyaji, T ;
McLeroy, P ;
Nibhanupudy, B ;
Li, SJ ;
Star, RA .
KIDNEY INTERNATIONAL, 2001, 60 (06) :2118-2128
[5]   GADOLINIUM-DTPA ENHANCED DYNAMIC MR IMAGING IN THE EVALUATION OF CISPLATINUM NEPHROTOXICITY [J].
FRANK, JA ;
CHOYKE, PL ;
GIRTON, ME ;
AUSTIN, HA ;
SIEVENPIPER, C ;
INSCOE, SW ;
BLACK, JL ;
CARVLIN, MJ ;
DWYER, AJ .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1989, 13 (03) :448-459
[6]   Acute renal failure in patients with sepsis in a surgical ICU: Predictive factors, incidence, comorbidity, and outcome [J].
Hoste, EAJ ;
Lameire, NH ;
Vanholder, RC ;
Benoit, DD ;
Decruyenaere, JMA ;
Colardyn, FA .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (04) :1022-1030
[7]   Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody [J].
Kobayashi, H ;
Wu, CC ;
Kim, MK ;
Paik, CH ;
Carrasquillo, JA ;
Brechbiel, MW .
BIOCONJUGATE CHEMISTRY, 1999, 10 (01) :103-111
[8]   Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: Comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core [J].
Kobayashi, H ;
Kawamoto, S ;
Saga, T ;
Sato, N ;
Hiraga, A ;
Ishimori, T ;
Akita, Y ;
Mamede, MH ;
Konishi, J ;
Togashi, K .
MAGNETIC RESONANCE IN MEDICINE, 2001, 46 (04) :795-802
[9]   Dendrimer-based nanosized MRI contrast agents [J].
Kobayashi, H ;
Brechbiel, MW .
CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2004, 5 (06) :539-549
[10]   Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure [J].
Kobayashi, H ;
Jo, SK ;
Kawamoto, S ;
Yasuda, H ;
Hu, XZ ;
Knopp, MV ;
Brechbiel, MW ;
Choyke, PL ;
Star, RA .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2004, 20 (03) :512-518