TGF-β Family Signaling in Mesenchymal Differentiation

被引：231

作者：

Grafe, Ingo ^{[1
]}

Alexander, Stefanie ^{[1
]}

Peterson, Jonathan R. ^{[2
]}

Snider, Taylor Nicholas ^{[3
]}

Levi, Benjamin ^{[2
]}

Lee, Brendan ^{[1
]}

Mishina, Yuji ^{[3
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Univ Michigan, Med Sch, Dept Surg, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Dent, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2018年 / 10卷 / 05期

基金：

美国国家卫生研究院;

关键词：

TRANSFORMING-GROWTH-FACTOR; BONE MORPHOGENETIC PROTEIN; NF-KAPPA-B; INDUCED OSTEOBLASTIC DIFFERENTIATION; HYPERTROPHIC CHONDROCYTE KINETICS; SATELLITE CELL-PROLIFERATION; PLURIPOTENT STEM-CELLS; TUMOR-NECROSIS-FACTOR; SKELETAL-MUSCLE MASS; IA RECEPTOR BMPRIA;

D O I：

10.1101/cshperspect.a022202

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-beta (TGF-(beta) family. This review focuses on the roles of TGF-beta family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes. We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-beta family signaling can drive human disease by affecting mesenchymal differentiation.

引用

页数：49

共 540 条

[1]

Characterization of Mononucleated Human Peripheral Blood Cells [J].

Ab Kadir, Ruzanna ;

Ariffin, Shahrul Hisham Zainal ;

Wahab, RohayaMegat Abdul ;

Kermani, Shabnam ;

Senafi, Sahidan .

SCIENTIFIC WORLD JOURNAL, 2012,

[2]

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: Antagonism by noggin [J].

Abe, E ;

Yamamoto, M ;

Taguchi, Y ;

Lecka-Czernik, B ;

O'Brien, CA ;

Economides, AN ;

Stahl, N ;

Jilka, RL ;

Manolagas, SC .

JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 (04) :663-673

[3]

Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription [J].

Afzal, F ;

Pratap, J ;

Ito, K ;

Ito, Y ;

Stein, JL ;

Van Winen, AJ ;

Stein, GS ;

Lian, JB ;

Javed, A .

JOURNAL OF CELLULAR PHYSIOLOGY, 2005, 204 (01) :63-72

[4]

Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon [J].

Agarwal, Shailesh ;

Loder, Shawn J. ;

Cholok, David ;

Peterson, Joshua ;

Li, John ;

Breuler, Christopher ;

Brownley, R. Cameron ;

Sung, Hsiao Hsin ;

Chung, Michael T. ;

Kamiya, Nobuhiro ;

Li, Shuli ;

Zhao, Bin ;

Kaartinen, Vesa ;

Davis, Thomas A. ;

Qureshi, Ammar T. ;

Schipani, Ernestina ;

Mishina, Yuji ;

Levi, Benjamin .

STEM CELLS, 2017, 35 (03) :705-710

[5]

Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[6]

The transcrintion factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 [J].

Akiyama, H ;

Chaboissier, MC ;

Martin, JF ;

Schedl, A ;

de Crombrugghe, B .

GENES & DEVELOPMENT, 2002, 16 (21) :2813-2828

[7]

REGULATION OF SKELETAL-MUSCLE SATELLITE CELL-PROLIFERATION AND DIFFERENTIATION BY TRANSFORMING GROWTH FACTOR-BETA, INSULIN-LIKE GROWTH FACTOR-I, AND FIBROBLAST GROWTH-FACTOR [J].

ALLEN, RE ;

BOXHORN, LK .

JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 138 (02) :311-315

[8]

INHIBITION OF SKELETAL-MUSCLE SATELLITE CELL-DIFFERENTIATION BY TRANSFORMING GROWTH-FACTOR-BETA [J].

ALLEN, RE ;

BOXHORN, LK .

JOURNAL OF CELLULAR PHYSIOLOGY, 1987, 133 (03) :567-572

[9]

TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation [J].

Alliston, T ;

Choy, L ;

Ducy, P ;

Karsenty, G ;

Derynck, R .

EMBO JOURNAL, 2001, 20 (09) :2254-2272

[10]

The perichondrium plays an important role in mediating the effects of TGF-β1 on endochondral bone formation [J].

Alvarez, J ;

Horton, J ;

Sohn, P ;

Serra, R .

DEVELOPMENTAL DYNAMICS, 2001, 221 (03) :311-321

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