Therapeutic approaches to Alzheimer's disease

被引：51

作者：

Thorsett, ED ^{[1
]}

Latimer, LH ^{[1
]}

机构：

[1] Elan Pharmaceut, S San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(00)00102-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several recent advances have provided new insights and possibilities in defining therapeutic targets for Alzheimer's disease. Of particular importance is the identification of the beta-secretase enzyme and the demonstration that immunization of a transgenic mouse model of Alzheimer's disease with A beta(1-42) peptide can prevent or alleviate neuropathological features of the disease.

引用

页码：377 / 382

页数：6

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