The optimal template effect in hippocampus studies of diseased populations

被引：452

作者：

Avants, Brian B. ^{[1
]}

Yushkevich, Paul ^{[1
]}

Pluta, John ^{[2
]}

Minkoff, David ^{[2
]}

Korczykowski, Marc ^{[2
]}

Detre, John ^{[2
]}

Gee, James C. ^{[1
]}

机构：

[1] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

来源：

NEUROIMAGE | 2010年 / 49卷 / 03期

关键词：

Diffeomorphic Deformable image registration; Human cortex; Template; Epilepsy; TEMPORAL-LOBE EPILEPSY; DEFORMATION-BASED SEGMENTATION; BRAIN MR-IMAGES; ATLAS; REGISTRATION; DIFFEOMORPHISMS; MORPHOMETRY; MODELS; SHAPE; CONSTRUCTION;

D O I：

10.1016/j.neuroimage.2009.09.062

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We evaluate the impact of template choice on template-based segmentation of the hippocampus in epilepsy four dataset-specific strategies are quantitatively contrasted the "closest to average" individual template, the average shape version of the closest to average template. a best appearance template and the best appearance and shape template proposed here and implemented in the open source toollkit Advanced Normalization Tools (ANTS) The cross-correlation similarity metric drives the correspondence model and is used consistently to determine the optimal appearance Minimum shape distance in the diffeomorphic space determines optimal shape Our evaluation results show that, with respect to gold-standard Manual labeling of hippocampi in epilepsy, optimal shape and appearance template construction Outperforms the other strategies for gaining data-derived templates Our results also show the improvement is most significant on the diseased side and insignificant on the healthy side Thus. the importance of the template increases when used to study pathology and may be less critical for normal control studies Furthermore, explicit geometric optimization of the shape component of the unbiased template positively impacts the study of diseased hippocampi. (C) 2009 Elsevier Inc All rights reserved

引用

页码：2457 / 2466

页数：10

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