Obesity and the Hypertensive Disorders of Pregnancy

被引：26

作者：

Callaway, Leonie Kaye ^{[1
]}

O'Callaghan, Michael ^{[2
]}

McIntyre, H. David ^{[3
]}

机构：

[1] Royal Brisbane & Womens Hosp, Herston, Qld 4029, Australia

[2] Mater Hosp, Dept Dev Paediat, Brisbane, Australia

[3] Univ Queensland, Princess Alexandra Hosp, Woolloongabba, Qld, Australia

来源：

HYPERTENSION IN PREGNANCY | 2009年 / 28卷 / 04期

关键词：

Hypertension; Pregnancy; Preeclampsia; Gestational hypertension; Obesity; BODY-MASS INDEX; MECHANISMS LINKING OBESITY; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; GESTATIONAL HYPERTENSION; RISK-FACTORS; GROWTH RESTRICTION; MATERNAL OBESITY; ADIPOSE-TISSUE; FATTY-ACIDS;

D O I：

10.3109/10641950802629626

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Overweight and obesity have a strong association with the development of hypertensive disorders of pregnancy. However, the mechanisms underpinning this relationship are not clear. Obesity is associated with insulin resistance, endothelial dysfunction, hypertension dyslipidaemia, inflammatory upregulation, alteration in immune function and prothrombotic changes. These changes may contribute to the development of hypertensive disorders of pregnancy, by influencing placentation, endothelial function, and inflammation. The genetic predisposition for hypertensive disorders of pregnancy needs to be examined in the context of obesity. Common antecedents such as dietary factors and inadequate physical activity might also explain the relationship between hypertensive disorders of pregnancy and obesity. This review is concluded with a synopsis and recommendations for further research.

引用

页码：473 / 493

页数：21

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