Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors

被引：9

作者：

Ferretti, G

Dukat, M

Giannella, M

Piergentili, A

Pigini, M

Quaglia, W

Damaj, MI

Martin, BR

Glennon, RA ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Med Chem, Richmond, VA 23298 USA

[2] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

[3] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(02)01031-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A total of 20 substituted analogues of nicotine (1a) and homoazanicotine (3a) were examined in order to determine whether or not they might bind in a similar manner at alpha4beta2 nicotinic acetocholinergic (nACh) receptors. It was found that parallel structural changes in the two series resulted in parallel shifts in affinity. Evidence suggests that the two series are binding in a comparable fashion. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：733 / 735

页数：3

共 19 条

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