Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure

被引：50

作者：

Heo, JH

Kim, SH

Lee, KY

Kim, EH

Chu, CK

Nam, JM

机构：

[1] Yonsei Univ, Coll Med, Dept Neurol, Brain Korea Project Med Sci 21, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Dept Prevent Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea

来源：

STROKE | 2003年 / 34卷 / 06期

关键词：

metalloproteinases; stroke; ischemic; thrombolytic therapy;

D O I：

10.1161/01.STR.0000073788.81170.1C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. Methods-Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers were examined for MMP-2 and MMP-9 by both enzyme-linked immunosorbent assays and zymography. Results-The arteries were recanalized in 15 patients but not in the other 8. The MMP-9 plasma level was significantly higher in patients whose arteries were not recanalized. Conclusions-MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus.

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收藏

页码：E48 / E50

页数：3

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