Regulation of microtubules in cell migration

被引：249

作者：

Watanabe, T ^{[1
]}

Noritake, J ^{[1
]}

Kaibuchi, K ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Cell Pharmacol, Nagoya, Aichi 4668550, Japan

来源：

TRENDS IN CELL BIOLOGY | 2005年 / 15卷 / 02期

关键词：

D O I：

10.1016/j.tcb.2004.12.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Directional cell migration is a fundamental process in all organisms that is stringently regulated during tissue development, chemotaxis and wound healing. Migrating cells have a polarized morphology with an asymmetrical distribution of signaling molecules and the cytoskeleton. Microtubules are indispensable for the directional migration of certain cells. Recent studies have shown that Rho family GTPases, which are key regulators of cell migration, affect microtubules, in addition to the actin cytoskeleton and adhesion. Rho family GTPases capture and stabilize microtubules through their effectors at the cell cortex, leading to a polarized microtubule array; in turn, microtubules modulate the activities of Rho family GTPases. In this article, we discuss how a polarized microtubule array is established and how microtubules facilitate cell migration.

引用

页码：76 / 83

页数：8

共 71 条

[1] CLASPs are CLIP-115 and-170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts [J].

Akhmanova, A ;

Hoogenraad, CC ;

Drabek, K ;

Stepanova, T ;

Dortland, B ;

Verkerk, T ;

Vermeulen, W ;

Burgering, BM ;

De Zeeuw, CI ;

Grosveld, F ;

Galjart, N .

CELL, 2001, 104 (06) :923-935

[2] Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein β subunits and the yeast response regulator protein Skn7 [J].

Alberts, AS ;

Bouquin, N ;

Johnston, LH ;

Treisman, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (15) :8616-8622

[3] Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase [J].

Amano, M ;

Kaneko, T ;

Maeda, A ;

Nakayama, M ;

Ito, M ;

Yamauchi, T ;

Goto, H ;

Fukata, Y ;

Oshiro, N ;

Shinohara, A ;

Iwamatsu, A ;

Kaibuchi, K .

JOURNAL OF NEUROCHEMISTRY, 2003, 87 (03) :780-790

[4]

Barth AIM, 2002, J CELL SCI, V115, P1583

[5] Rho and Rac take center stage [J].

Burridge, K ;

Wennerberg, K .

CELL, 2004, 116 (02) :167-179

[6] Tea2p kinesin is involved in spatial microtubule organization by transporting Tip1p on microtubules [J].

Busch, KE ;

Hayles, J ;

Nurse, P ;

Brunner, D .

DEVELOPMENTAL CELL, 2004, 6 (06) :831-843

[7] Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation [J].

Carvalho, P ;

Gupta, ML ;

Hoyt, MA ;

Pellman, D .

DEVELOPMENTAL CELL, 2004, 6 (06) :815-829

[8] Surfing on microtubule ends [J].

Carvalho, P ;

Tirnauer, JS ;

Pellman, D .

TRENDS IN CELL BIOLOGY, 2003, 13 (05) :229-237

[9] The oncoprotein 18/stathmin family of microtubule destabilizers [J].

Cassimeris, L .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (01) :18-24

[10] Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid [J].

Cook, TA ;

Nagasaki, T ;

Gundersen, GG .

JOURNAL OF CELL BIOLOGY, 1998, 141 (01) :175-185

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