Transcriptional control: Imprinting insulation

被引：60

作者：

Wolffe, AP ^{[1
]}

机构：

[1] Sangamo Biosci Inc, Point Richmond Tech Ctr, Richmond, CA 94804 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(00)00534-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies on the transcriptional regulation of two linked, imprinted genes, Igf2 and H19, have provided evidence for a novel mechanism of epigenetic control. DNA methylation controls the activity of an insulator element located between the two linked genes by regulating the binding of the zinc-finger protein CTCF. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：R463 / F465

页数：3

共 26 条

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