Epigenelics - DNA-based mirror of our environment?

被引：20

作者：

Cooney, Craig A. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72205 USA

来源：

DISEASE MARKERS | 2007年 / 23卷 / 1-2期

关键词：

maternal nutrition; epigenetics; imprinting; methylation; acetylation; DNA; histones; expression; behavior; stress; glucocorticoid; hypothalamic-pituitary-adrenal; glucose; diabetes; metabotomics; reproduction; development; diet; mouse; rat; fox; human; agouti; axin; star; phenotype; genotype; GATACCA;

D O I：

10.1155/2007/394034

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Epigenetics affects health, appearance and behavior and propagates mammalian phenotypes across generations. Nutrients, drugs and behavior can all direct changes in epigenetics. In at least some cases, these directed changes are propagated across generations. This range of influences on epigenetics suggests that epigenetics is highly interactive with the environment. Changes in the environment may regularly change epigenetics and influence our future responses to the environment. The current research challenge is to understand these influences and use them to direct epigenetics toward improved health and longevity.

引用

页码：121 / 137

页数：17

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