Safety of intravitreal injection of bevacizumab in rabbit eyes

被引：67

作者：

Feiner, Leonard

Barr, Emily E.

Shui, Ying-Bo

Holekamp, Nancy M.

Brantley, Milam A.

机构：

[1] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA

[2] Barnes Retina Inst, St Louis, MO USA

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2006年 / 26卷 / 08期

关键词：

bevacizumab (Avastin); ranibizumab (Lucentis); rabbit; electroretinogram; safety;

D O I：

10.1097/01.iae.0000230717.85319.f5

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To evaluate the safety of intravitreal injection of bevacizumab in rabbits using electrophysiological testing and histopathologic analysis. Methods: New Zealand albino rabbits were injected in one eye with control antibody (n = 2), 0.05 mL of bevacizumab (n = 3), or 0.2 mL of bevacizumab (n = 3). Electroretinograms were obtained 1 week and 4 weeks after injection. Histologic analysis was performed after completion of the electroretinographic studies. Results: No statistical differences were seen in scotopic and photopic a- and b-wave amplitudes between untreated control and bevacizumab-injected eyes. No histopathologic differences were identified between untreated control and bevacizumab-injected eyes. Conclusion: Our study did not find evidence of retinal toxicity from a single intravitreal injection of bevacizumab in rabbits.

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收藏

页码：882 / 888

页数：7

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