Rapamycin induces transforming growth factor-β production by lymphocytes

被引：33

作者：

Dodge, IL ^{[1
]}

Demirci, G ^{[1
]}

Strom, TB ^{[1
]}

Li, XC ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Immunol, Boston, MA 02215 USA

来源：

TRANSPLANTATION | 2000年 / 70卷 / 07期

关键词：

D O I：

10.1097/00007890-200010150-00020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Under certain conditions rapamycin and transforming growth factor- (TGF) beta have similar immunoregulatory effects, suggesting a potential functional link between rapamycin and TGF-beta. Methods. Splenic leukocytes were stimulated in vitro with anti-CD3 or with allogeneic cells in vivo in the presence or absence of rapamycin. TGF-beta production by activated lymphocytes was quantitated using ELISA. Results. Splenic leukocytes from BALB/c mice that were primed with allogeneic cells and conditioned with rapamycin in vivo as well as splenic leukocytes that were treated with rapamycin in vitro produced significantly higher levels of TGF-beta upon anti-CD3 stimulation as compared with untreated controls. Conclusion. Our data suggest that rapamycin can program activated lymphocytes to produce TGF-beta. Thus, the immunosuppressive effects of rapamycin may be partially mediated by TGF-beta.

引用

页码：1104 / 1106

页数：3

共 14 条

[1] Immunopharmacology of rapamycin [J].

Abraham, RT ;

Wiederrecht, GJ .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :483-510

[2] Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling [J].

Abraham, RT .

CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (03) :330-336

[3]

AHUJA SS, 1993, J IMMUNOL, V150, P3109

[4]

BORDER WA, 1994, NEW ENGL J MED, V331, P1286

[5] Mechanism of TGF beta receptor inhibition by FKBP12 [J].

Chen, YG ;

Liu, F ;

Massague, J .

EMBO JOURNAL, 1997, 16 (13) :3866-3876

[6]

KEHRL JH, 1989, J IMMUNOL, V143, P1868

[7] PROTECTIVE EFFECT OF TRANSFORMING GROWTH FACTOR-BETA-1 ON EXPERIMENTAL AUTOIMMUNE-DISEASES IN MICE [J].

KURUVILLA, AP ;

SHAH, R ;

HOCHWALD, GM ;

LIGGITT, HD ;

PALLADINO, MA ;

THORBECKE, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2918-2921

[8]

Maeda H, 1996, J IMMUNOL, V156, P73

[9]

RAJU GP, 1994, TRANSPLANTATION, V58, P392, DOI 10.1097/00007890-199408150-00029

[10] RAPAMYCIN INHIBITS TRANSPLANT VASCULOPATHY IN LONG-SURVIVING RAT-HEART ALLOGRAFTS [J].

SCHMID, C ;

HEEMANN, U ;

AZUMA, H ;

TILNEY, NL .

TRANSPLANTATION, 1995, 60 (07) :729-733

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