Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis

被引：356

作者：

Wang, Q ^{[1
]}

Khillan, J ^{[1
]}

Gadue, P ^{[1
]}

Nishikura, K ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2000年 / 290卷 / 5497期

关键词：

D O I：

10.1126/science.290.5497.1765

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The members of the ADAR (adenosine deaminase acting on RNA) gene family are involved in site-selective RNA editing that changes adenosine residues of target substrate RNAs to inosine, Analysis of staged chimeric mouse embryos with a high contribution from embryonic stem cells with a functional null allele for ADAR1 revealed a heterozygous embryonic-lethal phenotype. Most ADAR1(+/-) chimeric embryos died before embryonic day 14 with defects in the hematopoietic system. Our results suggest the importance of regulated Levels of ADAR1 expression, which is critical for embryonic erythropoiesis in the liver.

引用

页码：1765 / 1768

页数：4

共 28 条

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