Mass transfer limitations to the performance of membrane bioartificial liver support devices

被引：58

作者：

Catapano, G

机构：

[1] Department of Chemical Engineering, University of Calabria, Arcavacata di Rende (CS), Italy

[2] Department of Chemical Engineering, University of Calabria, I- 87036 Arcavacata di Rende (CS), Italy

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 1996年 / 19卷 / 01期

关键词：

bioartificial; hepatocytes; liver; mass transfer; membrane; support;

D O I：

10.1177/039139889601900105

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A number of membrane bioartificial devices have been proposed for liver support. However, their design does not yet ensure the successful treatment of acute liver insufficiency. In this paper, the Author reviews the limitations of the mass transport phenomena to the performance of a membrane bioartificial liver support device. First of all the requirements that an optimal membrane bioartificial liver support device has to meet for the therapy to be effective are presented. On these grounds, the issues that are still to be addressed to optimize the performance of such devices are discussed: particular attention is devoted to the mass transport phenomena in each region of the membrane bioartificial device. Finally, the main transport features of the membrane bioartificial liver support devices proposed so far are illustrated and examined.

引用

页码：18 / 35

页数：18

共 70 条

[21] HEPATOCYTE FUNCTION AND EXTRACELLULAR-MATRIX GEOMETRY - LONG-TERM CULTURE IN A SANDWICH CONFIGURATION [J].