Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases

被引：70

作者：

Pyne, S

Kong, KC

Darroch, PI

机构：

[1] Univ Strathclyde, Strathclyde Inst Biomed Res, Dept Physiol & Pharmacol, Glasgow G4 0NR, Lanark, Scotland

[2] Wake Forest Univ Hlth Sci, Dept Med, Ctr Human Genome, Winston Salem, NC 27157 USA

[3] CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

lipid phosphate phosphatase; lysophosphatidic acid; phosphatidic acid; sphingosine; 1-phosphate; sphingosine 1-phosphate phosphatase;

D O I：

10.1016/j.semcdb.2004.05.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (UP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：491 / 501

页数：11

共 89 条

[1] G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells [J].