Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging

被引:914
作者
Ilver, D
Arnqvist, A
Ögren, J
Frick, IM
Kersulyte, D
Incecik, ET
Berg, DE
Covacci, A
Engstrand, L
Borén, T [1 ]
机构
[1] Umea Univ, Dept Oral Biol, SE-90187 Umea, Sweden
[2] Umea Univ, Dept Microbiol, SE-90187 Umea, Sweden
[3] Univ Lund, Dept Cell & Mol Biol, SE-22100 Lund, Sweden
[4] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[5] Immunobiol Res Inst Siena, I-53100 Siena, Italy
[6] Univ Hosp, Dept Clin Microbiol & Canc Epidemiol, SE-75185 Uppsala, Sweden
关键词
D O I
10.1126/science.279.5349.373
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Le(b)) histo-blood group antigen. The Le(b)-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Le(b)-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.
引用
收藏
页码:373 / 377
页数:5
相关论文
共 32 条
  • [1] Blaser M J, 1993, Trends Microbiol, V1, P255, DOI 10.1016/0966-842X(93)90047-U
  • [2] Not all Helicobacter pylori strains are created equal: Should all be eliminated?
    Blaser, MJ
    [J]. LANCET, 1997, 349 (9057) : 1020 - 1022
  • [3] BLASER MJ, 1996, SCI AM, V274, P92
  • [4] IDENTIFICATION OF A ZP3-BINDING PROTEIN ON ACROSOME-INTACT MOUSE SPERM BY PHOTOAFFINITY CROSS-LINKING
    BLEIL, JD
    WASSARMAN, PM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) : 5563 - 5567
  • [5] ATTACHMENT OF HELICOBACTER-PYLORI TO HUMAN GASTRIC EPITHELIUM MEDIATED BY BLOOD-GROUP ANTIGENS
    BOREN, T
    FALK, P
    ROTH, KA
    LARSON, G
    NORMARK, S
    [J]. SCIENCE, 1993, 262 (5141) : 1892 - 1895
  • [6] BOREN T, UNPUB
  • [7] BOREN T, 1994, SCI MED, V1, P28
  • [8] Use of photocrosslinkers in cell biology
    Brunner, J
    [J]. TRENDS IN CELL BIOLOGY, 1996, 6 (04) : 154 - 157
  • [9] ORDERED COSMID LIBRARY AND HIGH-RESOLUTION PHYSICAL-GENETIC MAP OF HELICOBACTER-PYLORI STRAIN NCTC11638
    BUKANOV, NO
    BERG, DE
    [J]. MOLECULAR MICROBIOLOGY, 1994, 11 (03) : 509 - 523
  • [10] cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
    Censini, S
    Lange, C
    Xiang, ZY
    Crabtree, JE
    Ghiara, P
    Borodovsky, M
    Rappuoli, R
    Covacci, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14648 - 14653