Integrins and cadherins as therapeutic targets in fibrosis

被引：52

作者：

Agarwal, Sandeep K. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Med, Biol Inflammat Ctr, Sect Allergy Immunol & Rheumatol, Houston, TX 77030 USA

来源：

FRONTIERS IN PHARMACOLOGY | 2014年 / 5卷

关键词：

integrins; cadherins; fibrosis; macrophage; fibroblasts; epithelial cells; GROWTH-FACTOR-BETA; IDIOPATHIC PULMONARY-FIBROSIS; SYSTEMIC-SCLEROSIS; MESENCHYMAL TRANSITION; CELL-ADHESION; N-CADHERIN; INCREASED EXPRESSION; ALPHA-V-BETA-5; INTEGRIN; RHEUMATOID-ARTHRITIS; DERMAL FIBROBLASTS;

D O I：

10.3389/fphar.2014.00131

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Fibrosis is the excessive deposition of extracellular matrix proteins into tissues leading to scar formation, disruption of normal tissue architecture and organ failure. Despite the large clinical impact of fibrosis, treatment options are limited. Adhesion molecules, in particular alpha v beta 6 and alpha 3 beta 1 integrins and cadherin-11, have been demonstrated to be important mediators of tissue fibrosis. These data are reviewed here and provide the foundation for these molecules to be potential therapeutic targets for patients with fibrotic diseases.

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页数：7

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