Prevention of type 2 diabetes in a primary health care setting - Interim results from the Greater Green Triangle (GGT) Diabetes Prevention Project

被引:39
作者
Kilkkinen, Annamari [1 ]
Heistaro, Sami
Laatikainen, Tiina
Janus, Edward
Chapman, Anna
Absetz, Pilvikki
Dunbar, James
机构
[1] Flinders Univ S Australia, Greater Green Triangle Univ Dept Rural Hlth, Adelaide, SA 5001, Australia
[2] Deakin Univ, Warrnambool, Vic 3280, Australia
[3] Natl Publ Hlth Inst, FI-00300 Helsinki, Finland
[4] Western Hosp, Dept Med, Footscray, Vic 3011, Australia
关键词
type 2 diabetes mellitus; life style; intervention studies; primary prevention; primary health care;
D O I
10.1016/j.diabres.2006.09.027
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although clinical trials have shown that lifestyle modifications reduce the risk of type 2 diabetes, translating lessons from trials to primary care remains a challenge. The aim of the study was to evaluate efficacy and feasibility of primary care-based diabetes prevention model with modest resource requirements in rural Australia. Three hundred and eleven subjects with at least a moderate risk of type 2 diabetes participated in a combined dietary and physical activity intervention. Clinical measurements and fasting blood samples were taken at the baseline and after intervention. After 3 months intervention, total (change -3.5%, p < 0.001) and LDL cholesterol (-4.8%, p < 0.001) plasma levels as well as body mass index (-2.5%, p < 0.001), weight (-2.5%, p < 0.001), and waist (-1.6%, p < 0.001) and hip (-2.7%, p < 0.001) circumferences reduced significantly. A borderline reduction was found in triglyceride levels (-4.8%, p = 0.058) while no changes were observed in HDL cholesterol (+0.6%, p = 0.525), glucose (+0.06%, p = 0.386), or systolic (-0.98%, p = 0.095) or diastolic (- 1.06%, p = 0. 134) blood pressure levels. In conclusion, a lifestyle intervention improved health outcomes - especially obesity and blood lipids - in a population at high risk of developing type 2 diabetes. Our results suggest that the present model is effective and feasible to carry out in primary care settings. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:460 / 462
页数:3
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