Immunity and immunopathology to viruses: what decides the outcome?

被引：441

作者：

Rouse, Barry T. ^{[1
]}

Sehrawat, Sharvan ^{[2
]}

机构：

[1] Univ Tennessee, Dept Pathobiol, Coll Vet Med, Knoxville, TN 37996 USA

[2] Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HEPATITIS-C VIRUS; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; RESPIRATORY SYNCYTIAL VIRUS; VIRAL-INDUCED IMMUNOPATHOLOGY; INHIBITS ANTIGEN PRESENTATION; CENTRAL-NERVOUS-SYSTEM; TOLL-LIKE RECEPTOR-3; HERPES-SIMPLEX; DENDRITIC CELLS;

D O I：

10.1038/nri2802

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many viruses infect humans and most are controlled satisfactorily by the immune system with limited damage to host tissues. Some viruses, however, do cause overt damage to the host, either in isolated cases or as a reaction that commonly occurs after infection. The outcome is influenced by properties of the infecting virus, the circumstances of infection and several factors controlled by the host. In this Review, we focus on host factors that influence the outcome of viral infection, including genetic susceptibility, the age of the host when infected, the dose and route of infection, the induction of anti-inflammatory cells and proteins, as well as the presence of concurrent infections and past exposure to cross-reactive agents.

引用

页码：514 / 526

页数：13

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