Research on HLA-G: an update

被引：56

作者：

Favier, B. ^{[1
]}

LeMaoult, J. ^{[1
]}

Rouas-Freiss, N. ^{[1
]}

Moreau, P. ^{[1
]}

Menier, C. ^{[1
]}

Carosella, E. D. ^{[1
]}

机构：

[1] Hop St Louis, Commissariat Energie Atom DSV DRM, Serv Rech Hematoimmunol, IUH, F-75475 Paris 10, France

来源：

TISSUE ANTIGENS | 2007年 / 69卷 / 03期

关键词：

cancer; HLA-G; ILT; pregnancy; tolerance;

D O I：

10.1111/j.1399-0039.2006.00757.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule from the major histocompatibility complex, which was initially shown to confer protection to the fetus from her mother's immune system. The Third International Conference on HLA-G, held in 2003, showed that beyond its role in fetal-maternal tolerance, HLA-G exerts tolerogenic functions involved in transplant acceptance as well as in tumoral and viral immune escape. The Fourth International Conference, which took place in Paris on July 2006, counted 72 oral presentations and about 200 attendees from 25 countries. The reports presented brought new insight into HLA-G research, and we summarize here the major advances on the HLA-G biology that were reported. Abstracts for all presentations can be found in volume 68 issue number 4 of Tissue Antigens.

引用

页码：207 / 211

页数：5

共 8 条

[1] HLA-G suppresses proliferation of CD4+ T-lymphocytes [J].