DarkHorse: a method for genome-wide prediction of horizontal gene transfer

被引：119

作者：

Podell, Sheila ^{[1
]}

Gaasterland, Terry ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Institut Oceanog, Scripps Genome Ctr, La Jolla, CA 92093 USA

来源：

GENOME BIOLOGY | 2007年 / 8卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1186/gb-2007-8-2-r16

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new approach to rapid, genome-wide identification and ranking of horizontal transfer candidate proteins is presented. The method is quantitative, reproducible, and computationally undemanding. It can be combined with genomic signature and/or phylogenetic tree-building procedures to improve accuracy and efficiency. The method is also useful for retrospective assessments of horizontal transfer prediction reliability, recognizing orthologous sequences that may have been previously overlooked or unavailable. These features are demonstrated in bacterial, archaeal, and eukaryotic examples.

引用

页数：18

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