Panthenol as neuroprotectant: Study in a rat model of middle cerebral artery occlusion

被引：5

作者：

Onufriev, M. V. ^{[1
]}

Stepanichev, M. Yu. ^{[1
]}

Lazareva, N. V. ^{[1
]}

Katkovskaya, I. N. ^{[2
]}

Tishkina, A. O. ^{[1
]}

Moiseenok, A. G. ^{[2
]}

Gulyaeva, N. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia

[2] Inst Pharmacol & Biochem NAS Belarus, Sci Pract Ctr, Grodno, BELARUS

来源：

NEUROCHEMICAL JOURNAL | 2010年 / 4卷 / 02期

关键词：

panthenol; panthotenic acid; brain; ischemia; four vessel occlusion; stroke; PANTOTHENIC-ACID; ISCHEMIA; DAMAGE;

D O I：

10.1134/S181971241002011X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In vivo study of neuroprotective effects of D-panthenol has been performed on a rat model of middle cerebral artery occlusion (MCAO). Administration of panthenol (i.p., 200 mg/kg 24 h, 0.5 h before and 0.5 h, 24 h, 48 h after MCAO) significantly ameliorated neurological deficit 1-5 days after MCAO, reduced body weight loss and cortical damage induced by 30 min MCAO. The results are the first in vivo evidence for neuroprotective properties of D-panthenol and suggest that it has a good potential for treatment of neurological diseases.

引用

页码：148 / 152

页数：5

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