The role of brain-derived neurotrophic factor in different animal models of neuropathic pain

被引：45

作者：

Vanelderen, Pascal ^{[1
,3
]}

Rouwette, Tom ^{[2
,3
]}

Kozicz, Tamas ^{[2
]}

Roubos, Eric ^{[2
]}

Van Zundert, Jan ^{[1
]}

Heylen, Rene ^{[1
]}

Vissers, Kris ^{[3
]}

机构：

[1] Ziekenhuis Oost Limburg, Intens Care Med & Multidisciplinary Pain Ctr, Dept Anaesthesiol, Genk, Belgium

[2] Radboud Univ Nijmegen, Dept Cellular Anim Physiol, Fac Sci, NL-6525 ED Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Anaesthesiol Palliat & Chron Pain Therapy, NL-6525 ED Nijmegen, Netherlands

来源：

EUROPEAN JOURNAL OF PAIN | 2010年 / 14卷 / 05期

关键词：

Dorsal root ganglion; Neurotrophins; Sciatic nerve; Spinal nerve; Brain-derived neurotrophic factor; DORSAL-ROOT GANGLION; NERVE GROWTH-FACTOR; CHRONIC CONSTRICTION INJURY; PRIMARY AFFERENT NEURONS; PROTEIN-KINASE ACTIVATION; SPINAL GLIAL ACTIVATION; SCIATIC-NERVE; PERIPHERAL-NERVE; SENSORY NEURONS; MESSENGER-RNA;

D O I：

10.1016/j.ejpain.2009.09.006

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Even in present day pain therapy, neuropathic pain remains a challenge for clinicians to treat and a challenge for researchers to investigate. Different animal models have been developed to mimic neuropathic pain. Neurotrophins such as nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3 have been studied extensively in these models, yet few review articles concerning brain-derived neurotrophic factor have been published. This article reassesses the literature concerning brain-derived neurotrophic factor expression in the sciatic nerve chronic constriction injury model, the sciatic nerve transection model, the spinal nerve ligation model and the spinal nerve transection model and discusses differences in regulation of brain-derived neurotrophic factor between these models and their causality with neuropathic pain. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.

引用

页码：473.e1 / 473.e9

页数：9

共 86 条

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