Divalent metal-dependent regulation of hepcidin expression by MTF-1

被引：53

作者：

Balesaria, Sara ^{[1
]}

Ramesh, Bala ^{[1
]}

McArdle, Harry ^{[2
]}

Bayele, Henry K. ^{[1
]}

Srai, Surjit K. S. ^{[1
]}

机构：

[1] UCL, Div Biosci, Dept Struct & Mol Biol, London WC1E 6BT, England

[2] Rowett Res Inst, Aberdeen AB21 9SB, Scotland

来源：

FEBS LETTERS | 2010年 / 584卷 / 04期

关键词：

Zinc; Iron; Hepcidin; MRE-binding transcription factor-1; Metal response element; TRANSCRIPTION FACTOR MTF-1; IN-VITRO; FUNCTIONAL EXPRESSION; RESPONSIVE ELEMENTS; IRON TRANSPORTERS; BINDING ACTIVITY; PROTEIN-BINDING; DIETARY ZINC; DNA-BINDING; METALLOTHIONEIN;

D O I：

10.1016/j.febslet.2009.12.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1. Analysis of hepcidin mRNA and protein levels in hepatoma cells suggests that its expression may be regulated by divalent metal ions, with zinc inducing maximal effects on hepcidin levels. These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：719 / 725

页数：7

共 57 条

[1]

A novel mammalian iron-regulated protein involved in intracellular iron metabolism [J].

Abboud, S ;

Haile, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (26) :19906-19912

[2]

The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-1 expression in response to the essential metal zinc in visceral endoderm cells during early development [J].

Andrews, GK ;

Lee, DK ;

Ravindra, R ;

Lichtlen, P ;

Sirito, M ;

Sawadogo, M ;

Schaffner, W .

EMBO JOURNAL, 2001, 20 (05) :1114-1122

[3]

Inhibition of iron and copper uptake by iron, copper and zinc [J].

Arredondo, M ;

Martínez, R ;

Núñez, MT ;

Ruz, M ;

Olivares, M .

BIOLOGICAL RESEARCH, 2006, 39 (01) :95-102

[4]

Copper overload affects copper and iron metabolism in Hep-G2 cells [J].

Arredondo, M ;

Cambiazo, V ;

Tapia, L ;

González-Agüero, M ;

Núñez, MT ;

Uauy, R ;

González, M .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2004, 287 (01) :G27-G32

[5]

Cis and trans regulation of hepcidin expression by upstream stimulatory factor [J].

Bayele, Henry K. ;

McArdle, Harry ;

Srai, Surjit K. S. .

BLOOD, 2006, 108 (13) :4237-4245

[6]

Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism [J].

Bayele, Henry K. ;

Srai, Surjit Kaila S. .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (09) :1185-1188

[7]

The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals [J].

Bittel, D ;

Dalton, T ;

Samson, SLA ;

Gedamu, L ;

Andrews, GK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) :7127-7133

[8]

Differential expression of stress-inducible proteins in chronic hepatic iron overload [J].

Brown, Kyle E. ;

Broadhurst, Kimberly A. ;

Mathahs, M. Meleah ;

Weydert, Jamie .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 223 (02) :180-186

[9]

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice [J].

Canonne-Hergaux, F ;

Zhang, AS ;

Ponka, P ;

Gros, P .

BLOOD, 2001, 98 (13) :3823-3830

[10]

Separate pathways for cellular uptake of ferric and ferrous iron [J].

Conrad, ME ;

Umbreit, JN ;

Moore, EG ;

Hainsworth, LN ;

Porubcin, M ;

Simovich, MJ ;

Nakada, MT ;

Dolan, K ;

Garrick, MD .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 279 (04) :G767-G774

← 1 2 3 4 5 6 →