Survivin and leukemia

被引：37

作者：

Cong, XL

Han, ZC ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China

[2] Chinese Acad Med Sci, Hosp Blood Dis, Tianjin 300020, Peoples R China

[3] Peking Union Med Coll, Tianjin 300020, Peoples R China

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2004年 / 80卷 / 03期

关键词：

survivin; antiapoptosis function; hematopoietic malignancies; therapeutic target;

D O I：

10.1532/IJH97.A10408

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Survivin is a unique member of the inhibitor-of-apoptosis family. Survivin plays a role in the proliferation and survival of normal hematopoietic cells. Survivin expression is aberrantly enhanced in most cancers and hematopoietic malignancies. Survivin is an attractive therapeutic target, and various approaches to targeting survivin have been tested in vitro and in vivo. We review here progress in survivin research. (C) 2004 The Japanese Society of Hematology.

引用

页码：232 / 238

页数：7

共 63 条

[1] Expression and prognostic significance of survivin in de novo acute myeloid leukaemia [J].