Vitamin D Intake Needed to Maintain Target Serum 25-Hydroxyvitamin D Concentrations in Participants with Low Sun Exposure and Dark Skin Pigmentation Is Substantially Higher Than Current Recommendations

被引:84
作者
Hall, Laura M. [1 ,4 ]
Kimlin, Michael G. [5 ]
Aronov, Pavel A. [2 ,3 ]
Hammock, Bruce D. [2 ,3 ]
Slusser, James R. [6 ]
Woodhouse, Leslie R. [4 ]
Stephensen, Charles B. [1 ,4 ]
机构
[1] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA
[3] Univ Calif Davis, Ctr Canc, Davis, CA 95616 USA
[4] USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA
[5] Queensland Univ Technol, AusSun Res Lab, Inst Biomed Innovat, Kelvin Grove, Qld 4059, Australia
[6] Colorado State Univ, Nat Resource Ecol Lab, Ft Collins, CO 80523 USA
关键词
ULTRAVIOLET-RADIATION EXPOSURE; DIELS-ALDER DERIVATIZATION; D METABOLITES; UV-RADIATION; CUTANEOUS SYNTHESIS; US POPULATION; PHOTOSYNTHESIS; PREVITAMIN-D3; ASSOCIATION; PERSPECTIVE;
D O I
10.3945/jn.109.115253
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
Cutaneous cholecalciferol synthesis has not been considered in making recommendations for vitamin D intake. Our objective was to model the effects of sun exposure, vitamin D intake, and skin reflectance (pigmentation) on serum 25-hydroxyvitamin D (25[OH]D) in young adults with a wide range of skin reflectance and sun exposure. Four cohorts of participants (n = 72 total) were studied for 7-8 wk in the fall, winter, spring, and summer in Davis, CA [38.5 degrees N, 121.7 degrees W, Elev. 49 ft (15 m)]. Skin reflectance was measured using a spectrophotometer, vitamin D intake using food records, and sun exposure using polysulfone dosimeter badges. A multiple regression model (R-2 = 0.55; P < 0.0001) was developed and used to predict the serum 25(OH)D concentration for participants with low [median for African ancestry (AA)] and high [median for European ancestry (EA)] skin reflectance and with low (20th percentile, similar to 20 min/d, similar to 18% body surface area (BSA) exposed) and high (80th percentile, similar to 90 min/d, similar to 35% BSA exposed) sun exposure, assuming an intake of 200 IU/d (5 ug/d). Predicted serum 25(OH)D concentrations for AA individuals with low and high sun exposure in the winter were 24 and 42 nmol/L and in the summer were 40 and 60 nmol/L. Corresponding values for EA individuals were 35 and 60 nmol/L in the winter and in the summer were 58 and 85 nmol/L. To achieve 25(OH)D >= 75 nmol/L, we estimate that EA individuals with high sun exposure need 1300 IU/d vitamin D intake in the winter and AA individuals with low sun exposure need 2100-3100 IU/d year-round. J. Nutr. 140: 542-550, 2010.
引用
收藏
页码:542 / 550
页数:9
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