Changes in perceptual speed and white matter microstructure in the corticospinal tract are associated in very old age

被引:52
作者
Lovden, Martin [1 ,2 ,3 ]
Kohncke, Ylva [1 ,2 ]
Laukka, Erika J. [1 ,2 ]
Kalpouzos, Gregoria [1 ,2 ]
Salami, Alireza [1 ,2 ,5 ]
Li, Tie-Qiang [4 ]
Fratiglioni, Laura [1 ,2 ,6 ]
Backman, Lars [1 ,2 ]
机构
[1] Karolinska Inst, Aging Res Ctr, S-11330 Stockholm, Sweden
[2] Stockholm Univ, S-10691 Stockholm, Sweden
[3] Max Planck Inst Human Dev, Ctr Lifespan Psychol, Berlin, Germany
[4] Karolinska Inst, Dept Med Phys, S-11330 Stockholm, Sweden
[5] Umea Ctr Funct Brain Imaging, Umea, Sweden
[6] Stockholm Gerontol Res Ctr, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
Cognitive performance; Longitudinal; Structural equation modeling; White matter microstructure; Cognitive aging; HUMAN BRAIN; PROCESSING-SPEED; ADULT AGE; LIFE-SPAN; SPATIAL STATISTICS; COGNITIVE DECLINE; MEMORY; INTEGRITY; POPULATION; DISCONNECTION;
D O I
10.1016/j.neuroimage.2014.08.020
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The integrity of the brain's white matter is important for neural processing and displays age-related differences, but the contribution of changes in white matter to cognitive aging is unclear. We used latent change modeling to investigate this issue in a sample of very old adults (aged 81-103 years) assessed twice with a retest interval of 2.3 years. Using diffusion-tensor imaging, we probed white matter microstructure by quantifying mean fractional anisotropy and mean diffusivity of six major white matter tracts. Measures of perceptual speed, episodic memory, letter fluency, category fluency, and semantic memory were collected. Across time, alterations of white matter microstructure in the corticospinal tract were associated with decreases of perceptual speed. This association remained significant after statistically controlling for changes in white matter microstructure in the entire brain, in the other demarcated tracts, and in the other cognitive abilities. Changes in brain volume also did not account for the association. We conclude that white matter microstructure is a potent correlate of changes in sensorimotor aspects of behavior in very old age, but that it is unclear whether its impact extends to higher-order cognition. (c) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:520 / 530
页数:11
相关论文
共 62 条
[1]
Disruption of large-scale brain systems in advanced aging [J].
Andrews-Hanna, Jessica R. ;
Snyder, Abraham Z. ;
Vincent, Justin L. ;
Lustig, Cindy ;
Head, Denise ;
Raichle, Marcus E. ;
Buckner, Randy L. .
NEURON, 2007, 56 (05) :924-935
[2]
[Anonymous], 1994, Lifespan developmental psychology, DOI DOI 10.4324/9781315792712-10
[3]
Unified segmentation [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2005, 26 (03) :839-851
[4]
Linking cognitive aging to alterations in dopamine neurotransmitter functioning: Recent data and future avenues [J].
Backman, Lars ;
Lindenberger, Ulman ;
Li, Shu-Chen ;
Nyberg, Lars .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2010, 34 (05) :670-677
[5]
White matter structural decline in normal ageing: A prospective longitudinal study using tract-based spatial statistics [J].
Barrick, Thomas R. ;
Charlton, Rebecca A. ;
Clark, Chris A. ;
Markus, Hugh S. .
NEUROIMAGE, 2010, 51 (02) :565-577
[6]
Multiple indicators of age-related differences in cerebral white matter and the modifying effects of hypertension [J].
Burgmans, S. ;
van Boxtel, M. P. J. ;
Gronenschild, E. H. B. M. ;
Vuurman, E. F. P. M. ;
Hofman, P. ;
Uylings, H. B. M. ;
Jolles, J. ;
Raz, N. .
NEUROIMAGE, 2010, 49 (03) :2083-2093
[7]
Carroll B J., 1993, Human cognitive abilities: A survey of factor-analytical studies
[8]
The rises and falls of disconnection syndromes [J].
Catani, M ;
Ffytche, DH .
BRAIN, 2005, 128 :2224-2239
[9]
A diffusion tensor imaging tractography atlas for virtual in vivo dissections [J].
Catani, Marco ;
Thiebaut de Schotten, Michel .
CORTEX, 2008, 44 (08) :1105-1132
[10]
Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline [J].
Charlton, R. A. ;
Schiavone, F. ;
Barrick, T. R. ;
Morris, R. G. ;
Markus, H. S. .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (01) :13-19