Targeting vascular endothelial growth factor and angiogenesis for the treatment of colorectal cancer

被引：48

作者：

Collins, TS ^{[1
]}

Hurwitz, HI ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med Oncol, Durham, NC 27710 USA

来源：

SEMINARS IN ONCOLOGY | 2005年 / 32卷 / 01期

关键词：

D O I：

10.1053/j.seminoncol.2004.09.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis, the development and proliferation of new blood vessels, is critical for the growth of tumors. The process of new blood vessel formation is under complex control from a variety of pro- and anti-angiogenesis factors. By identifying and understanding these factors, new therapies have been developed to inhibit tumor growth and survival by blocking tumor-related angiogenesis. Recent success with the monoclonal antibody against vascular endothelial growth factor (VEGF; bevacizumab) in a large, randomized, phase III study has provided a critical proof of principle for this therapeutic area. This review will outline the biology of angiogenesis in colorectal cancer and discuss the current status of angiogenesis inhibition in its treatment. © 2005 Elsevier Inc. All rights reserved.

引用

页码：61 / 68

页数：8

共 95 条

[1]

[Anonymous], 2004, Cancer Facts and Figures

[2]

ASANO M, 1995, CANCER RES, V55, P5296

[3]

Bellamy WT, 1999, CANCER RES, V59, P728

[4]

BENSON AB, 2003, P AN M AM SOC CLIN, V22, P243

[5] Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent [J].

Bernatchez, PN ;

Soker, S ;

Sirois, MG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (43) :31047-31054

[6]

Bhargava P, 1999, CLIN CANCER RES, V5, P1989

[7]

BLANKE CD, 2002, P AN M AM SOC CLIN, V21, pA127

[8] INDIRECT ANGIOGENIC CYTOKINES UP-REGULATE VEGF AND BFGF GENE-EXPRESSION IN VASCULAR SMOOTH-MUSCLE CELLS, WHEREAS HYPOXIA UP-REGULATES VEGF EXPRESSION ONLY [J].

BROGI, E ;

WU, TG ;

NAMIKI, A ;

ISNER, JM .

CIRCULATION, 1994, 90 (02) :649-652

[9]

Ciardiello F, 2003, CLIN CANCER RES, V9, P1546

[10] AMINO-ACID AND CDNA SEQUENCES OF A VASCULAR ENDOTHELIAL-CELL MITOGEN THAT IS HOMOLOGOUS TO PLATELET-DERIVED GROWTH-FACTOR [J].

CONN, G ;

BAYNE, ML ;

SODERMAN, DD ;

KWOK, PW ;

SULLIVAN, KA ;

PALISI, TM ;

HOPE, DA ;

THOMAS, KA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) :2628-2632

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