Ouabain-like factor

被引：36

作者：

Goto, A

Yamada, K

机构：

[1] Univ Tokyo, Fac Med, Dept Internal Med 2, Bunkyo Ku, Tokyo 113, Japan

[2] Sanraku Hosp, Dept Human Dry Dock, Tokyo 101, Japan

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 1998年 / 7卷 / 02期

关键词：

D O I：

10.1097/00041552-199803000-00008

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Accumulated evidence has suggested that several sodium pump inhibitors, similar to cardiotonic steroids, are present in the human body. Ouabain-like factor, the most appealing candidate, has been found to be increased with high sodium intake and hypervolaemia, and in essential hypertension, mineralocorticoid hypertension, and pregnancy-induced hypertension. Furthermore, blocking the action of ouabain-like factor with digibind or a novel anti-ouabain agent lowers blood pressure in several models of hypertension. Several important questions remain, however, before it can be concluded that ouabain-like factor is indeed involved in the regulation of sodium homeostasis and blood pressure. (C) 1998 Rapid Science Ltd.

引用

页码：189 / 196

页数：8

共 63 条

[1]

Adair CD, 1996, AM J NEPHROL, V16, P529

[2]

AMASON SS, 1997, HYPERTENSION, V30, P494

[3] Ouabain is a potent inhibitor of aldosterone secretion and angiotensin action in the human adrenal [J].