Improved procedure for the enantioselective synthesis of dihydrooxazolo and dihydrothiazolo ring-fused 2-pyridones

被引：12

作者：

Chorell, Erik ^{[1
]}

Edvinsson, Sofie ^{[1
]}

Almqvist, Fredrik ^{[1
]}

机构：

[1] Umea Univ, Dept Chem, SE-90187 Umea, Sweden

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 18期

关键词：

2-Pyridone; PPTS; Peptidomimetic; Enantioselective; Pilicide; Curlicide; UROPATHOGENIC BACTERIA; PILUS BIOGENESIS; 2-PYRIDINONES; VIRULENCE;

D O I：

10.1016/j.tetlet.2010.02.162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Improved procedures to synthesize enantioselectively analogues of a peptidomimetic scaffold with high biological relevance have been developed. Experimental design led to a general method for the preparation of dihydrooxazolo ring-fused 2-pyridones in good yields and high enantiomeric purity. The knowledge gained from this was also used to improve the microwave-accelerated synthesis of dihydrothiazolo ring-fused 2-pyridones to give complete stereo retention and high yields. (C) 2010 Elsevier Ltd. All rights reserved.

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页码：2461 / 2463

页数：3

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