Brain Metastases

被引:38
作者
El Kamar, FG [1 ]
Posner, JB [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10021 USA
关键词
brain metastasis; supportive care; corticosteroids; seizures; venous thromboembolism;
D O I
10.1055/s-2004-861530
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Approximately 10% of patients with cancer develop brain metastases. Although usually appearing late in the course of the disease, the brain metastasis may be present before the primary cancer has been identified and may present as a single lesion or as multiple lesions. The diagnostic and therapeutic approach depends on the number and location of brain lesions and the stage of the cancer. Patients with brain metastases are rarely cured. However, appropriate treatment can improve both the quality and duration of the patient's life. Treatment must be directed not only at the brain metastasis (definitive care), but also at a multitude of other symptoms that plague patients with cancer and brain metastases (supportive care). Judicious selection of pharmacological agents can effectively treat many serious symptoms in patients with brain metastases, but injudicious selection of pharmacological agents, through side effects, may make the patients' quality of life worse. This article reviews some aspects of both definitive and supportive care with particular attention to the side effects of some commonly used pharmacological agents.
引用
收藏
页码:347 / 362
页数:16
相关论文
共 117 条
  • [1] Temozolomide for treating brain metastases
    Abrey, LE
    Christodoulou, C
    [J]. SEMINARS IN ONCOLOGY, 2001, 28 (04) : 34 - 42
  • [2] [Anonymous], 1978, ADV NEUROL
  • [3] Assouline-Dayan Y, 2002, SEMIN ARTHRITIS RHEU, V32, P94, DOI 10.1053/sarh.2002.33724
  • [4] Steroid myopathy in cancer patients
    Batchelor, TT
    Taylor, LP
    Thaler, HT
    Posner, JB
    DeAngelis, LM
    [J]. NEUROLOGY, 1997, 48 (05) : 1234 - 1238
  • [5] Surgery versus radiosurgery in the treatment of brain metastasis
    Bindal, AK
    Bindal, RK
    Hess, KR
    Shiu, A
    Hassenbusch, SJ
    Shi, WM
    Sawaya, R
    [J]. JOURNAL OF NEUROSURGERY, 1996, 84 (05) : 748 - 754
  • [6] Brown PD, 2002, NEUROSURGERY, V51, P656, DOI 10.1227/01.NEU.0000023713.44940.20
  • [7] Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: A double-blind, placebo-controlled study
    Bruera, E
    Strasser, F
    Palmer, JL
    Willey, J
    Calder, K
    Amyotte, G
    Baracos, V
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) : 129 - 134
  • [8] RADIATION-THERAPY FOR BRAIN METASTASES
    CAIRNCROSS, JG
    KIM, JH
    POSNER, JB
    [J]. ANNALS OF NEUROLOGY, 1980, 7 (06) : 529 - 541
  • [9] Caraceni A, 2000, CANCER-AM CANCER SOC, V89, P1145, DOI 10.1002/1097-0142(20000901)89:5<1145::AID-CNCR24>3.0.CO
  • [10] 2-X