The mammalian TRPC cation channels

被引：256

作者：

Vazquez, G ^{[1
]}

Wedel, BJ ^{[1
]}

Aziz, O ^{[1
]}

Trebak, M ^{[1
]}

Putney, JW ^{[1
]}

机构：

[1] NIEHS, Calcium Regulat Sect, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1742卷 / 1-3期

关键词：

ion channel; calcium channel; non-selective cation channel; TRP channel; TRPC channel; capacitative calcium entry; store-operated channel; second messenger-operated channel; inositol trisphosphate receptor; diacylglycerol; phospholipase C;

D O I：

10.1016/j.bbamcr.2004.08.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca2+-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as well as second messenger-operated channels in a variety of cell types. TRPC channels, together with other more distantly related channel families, make up the larger TRP channel superfamily. This review summarizes recent findings on the Structure, regulation and function of the apparently ubiquitous TRPC cation channels. Published by Elsevier B.V.

引用

页码：21 / 36

页数：16

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