Remote effects of cortical dysgenesis on the primary motor cortex: evidence from the silent period following transcranial magnetic stimulation

被引:23
作者
Cincotta, M
Borgheresi, A
Guidi, L
Macucci, M
Cosottini, M
Lambruschini, P
Benvenuti, F
Zaccara, G
机构
[1] Osped S Maria Nuova, Unita Operat Neurol, Azienda Sanit Firenze 10, I-50122 Florence, Italy
[2] Azienda Sanit 11 Empoli, Unita Operat Neurofisiopatol, Empoli, Italy
[3] Univ Pisa, Cattedra Radiol, Pisa, Italy
[4] INRCA Firenze, Unita Operat Geriatria I Fraticini, Florence, Italy
关键词
cortical dysgenesis; epilepsy; inhibition; motor cortex; silent period; transcranial magnetic stimulation;
D O I
10.1016/S1388-2457(00)00330-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: In cortical dysgenesis (CD), animal studies suggested abnormal cortico-cortical connections. Cerebral areas projecting to the primary motor cortex (M1) modulate the cortical silent period (CSP) following transcranial magnetic stimulation (TMS). Therefore, we used the CSP to investigate remote effects of CD on the M1. Methods: A detailed investigation, including single-pulse TMS and electrical nerve stimulation, was performed in 3 consecutive adults with focal CD located outside the M1 and in 18 controls. Two patients with unilateral CD were epileptic and treated with anti-epileptic drugs. One patient with focal CD on both sides had no history of seizures. Neurological examination was normal in all patients. Recordings were made from both first dorsal interosseous muscles. Results: In CD patients, the CSP was significantly lengthened contralaterally to the affected hemispheres. In treated patients with unilateral CD, the interside difference of the CSP duration was also significantly increased. In contrast, excitability threshold, peripheral and corticospinal motor conduction studies, and peripheral as well as ipsilateral silent periods were not significantly modified. Conclusions: Our findings indicate that focal CD outside the M1 may produce CSP modifications, which are likely due to changes of afferent control. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:1340 / 1345
页数:6
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