Eosinophilic esophagitis: Pathogenesis, genetics, and therapy

被引：145

作者：

Blanchard, Carine

Wang, Ning

Rothenberg, Marc E.

机构：

[1] Univ Cincinnati, Coll Med, Childrens Hosp, Ctr Med,Div Allergy & Immunol,Dept Pediat, Cincinnati, OH 45221 USA

[2] Univ Cincinnati, Coll Med, Childrens Hosp, Ctr Med,Div Human Genet,Dept Pediat, Cincinnati, OH 45221 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2006年 / 118卷 / 05期

关键词：

eosinophilic esophagitis; eosinophils; eosinophil-associated gastrointestinal disorder; allergy; eotaxin;

D O I：

10.1016/j.jaci.2006.07.038

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophilic esophagitis (EE) is a recently recognized disorder characterized by the accumulation of eosinophils in the esophagus. Symptoms of EE frequently mimic those of - gastroesophageal reflux disease, but the 2 diseases are quite distinct in terms of the histopathology and response to therapy. We demonstrate that EE involves the interplay of numerous genes, especially the eosinophil chemoattractant eotaxin-3, allowing molecular distinction from other forms of esophagitis and consideration of targeted therapeutic intervention.

引用

页码：1054 / 1059

页数：6

共 49 条

[1] Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice [J].

Akei, HS ;

Mishra, A ;

Blanchard, C ;

Rothenberg, ME .

GASTROENTEROLOGY, 2005, 129 (03) :985-994

[2] ESOPHAGEAL EOSINOPHILIA WITH DYSPHAGIA - A DISTINCT CLINICOPATHOLOGICAL SYNDROME [J].

ATTWOOD, SEA ;

SMYRK, TC ;

DEMEESTER, TR ;

JONES, JB .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (01) :109-116

[3] Eosinophilic oesophagitis: a novel treatment using Montelukast [J].

Attwood, SEA ;

Lewis, CJ ;

Bronder, CS ;

Morris, CD ;

Armstrong, GR ;

Whittam, J .

GUT, 2003, 52 (02) :181-185

[4] Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis [J].

Blanchard, C ;

Wang, N ;

Stringer, KF ;

Mishra, A ;

Fulkerson, PC ;

Abonia, JP ;

Jameson, SC ;

Kirby, C ;

Konikoff, MR ;

Collins, MH ;

Cohen, MB ;

Akers, R ;

Hogan, SP ;

Assa'ad, AH ;

Putnam, PE ;

Aronow, BJ ;

Rothenberg, ME .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (02) :536-547

[5] Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354) [J].

Blanchard, C ;

Mishra, A ;

Saito-Akei, H ;

Monk, P ;

Anderson, I ;

Rothenberg, ME .

CLINICAL AND EXPERIMENTAL ALLERGY, 2005, 35 (08) :1096-1103

[6] The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis [J].

Chae, SC ;

Park, YR ;

Oh, GJ ;

Lee, JH ;

Chung, HT .

IMMUNOGENETICS, 2005, 56 (10) :760-764

[7] Reflux esophagitis: Sequelae and differential diagnosis in infants and children including eosinophilic esophagitis [J].

Dahms, BB .

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 2004, 7 (01) :5-16

[8] Correlation of endoscopy and histology in the gastroesophageal mucosa in children - Are routine biopsies justified? [J].

Dahshan, A ;

Rabah, R .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2000, 31 (03) :213-216

[9] Pollen and eosinophilic esophagitis [J].

Fogg, MI ;

Ruchelli, E ;

Spergel, JM .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 112 (04) :796-797

[10] Eosinophilic esophagitis: it's not just kid's stuff [J].

Fox, VL ;

Nurko, S ;

Furuta, GT .

GASTROINTESTINAL ENDOSCOPY, 2002, 56 (02) :260-270

← 1 2 3 4 5 →