Calorimetric study of polymorphic forms of terfenadine

被引：10

作者：

Canotilho, J

Costa, FS

Sousa, AT

Redinha, JS

Leitao, MLP

机构：

[1] UNIV COIMBRA,FAC CIENCIAS & TECNOL,DEPT QUIM,P-3000 COIMBRA,PORTUGAL

[2] UNIV COIMBRA,FAC FARM,LAB GALENICA & TECNOL FARMACEUT,P-3000 COIMBRA,PORTUGAL

[3] UNIV COIMBRA,FAC FARM,LAB METODOS INSTRUMENTAIS ANAL,P-3000 COIMBRA,PORTUGAL

来源：

THERMOCHIMICA ACTA | 1997年 / 299卷 / 1-2期

关键词：

DSC; polymorphism; solution calorimetry; terfenadine; TG;

D O I：

10.1016/S0040-6031(97)00128-7

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Terfenadine polymorphic forms have been prepared by crystallization from ethanol and methanol solutions. The two polymorphs were studied by differential scanning calorimetry (DSC) and thermogravimetry (TG) in a temperature range between 233 and 443 K. From DSC data, structural differences between both forms were pointed out. Enthalpies for solution processes of the polymorphs in ethanol and in methanol were determined. Differences between both solid forms as well as between the solvent behaviour are well noted from the standard solution enthalpy values and from the variation of the enthalpy with concentration.

引用

页码：1 / 6

页数：6

共 9 条

[1]

STATISTICAL MECHANICAL STUDY OF HYDROPHOBIC INTERACTION .1. INTERACTION BETWEEN 2 IDENTICAL NONPOLAR SOLUTE PARTICLES [J].