Toll-like receptor 4 in atherosclerosis

被引：127

作者：

Li, Hongli ^{[1
]}

Sun, Baogui ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 1, Dept Cardiol, Shanghai 200080, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2007年 / 11卷 / 01期

关键词：

toll-like receptor 4; atherosclerosis; endothelial cells; vascular smooth muscle cells; adventitial fibroblasts; dendritic cells; macrophages; arterial remodelling;

D O I：

10.1111/j.1582-4934.2007.00011.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Toll-like receptor 4 (TLR4) is key regulators of both innate and adaptive immune responses. TLR4 recognizes pathogen-associated molecular patterns (PAMPs) and activates the inflammatory cells. The function of TLR4 in atherosclerosis has been investigated in mouse knockout studies and epidemiological studies of human TLR4 polymorphisms. These studies have shown that TLR4 function affects the initiation and progression of atherosclerosis. This article reviews the biological functions and clinical implications of TLR4 in atherosclerosis.

引用

页码：88 / 95

页数：8

共 56 条

[1] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[2] Association of the toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events [J].

Ameziane, N ;

Beillat, T ;

Verpillat, P ;

Chollet-Martin, S ;

Aumont, MC ;

Seknadji, P ;

Lamotte, M ;

Lebret, D ;

Ollivier, V ;

de Prost, D .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (12) :E61-E64

[3] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].

Arbour, NC ;

Lorenz, E ;

Schutte, BC ;

Zabner, J ;

Kline, JN ;

Jones, M ;

Frees, K ;

Watt, JL ;

Schwartz, DA .

NATURE GENETICS, 2000, 25 (02) :187-+

[4] Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways [J].

Björkbacka, H ;

Kunjathoor, VV ;

Moore, KJ ;

Koehn, S ;

Ordija, CM ;

Lee, MA ;

Means, T ;

Halmen, K ;

Luster, AD ;

Golenbock, DT ;

Freeman, MW .

NATURE MEDICINE, 2004, 10 (04) :416-421

[5]

Bobryshev YV, 1996, J SUBMICR CYTOL PATH, V28, P49

[6] Formation of Birbeck granule-like structures in vascular dendritic cells in human atherosclerotic aorta - Lag-antibody to epidermal Langerhans cells recognizes cells in the aortic wall [J].

Bobryshev, YV ;

Ikezawa, T ;

Watanabe, T .

ATHEROSCLEROSIS, 1997, 133 (02) :193-202

[7] Detection of Chlamydophila pineumoniae in dendritic cells in atherosclerotic lesions [J].

Bobryshev, YV ;

Cao, WP ;

Phoon, MC ;

Tran, D ;

Chow, VTK ;

Lord, RSA ;

Lu, JH .

ATHEROSCLEROSIS, 2004, 173 (02) :185-195

[8] Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions [J].

Bobryshev, YV ;

Lord, RSA .

CARDIOVASCULAR RESEARCH, 1998, 37 (03) :799-810

[9]

BOBRYSHEV YV, 1995, CARDIOVASC RES, V29, P689, DOI 10.1016/0008-6363(96)88642-1

[10] Endothelial dysfunction - A marker of atherosclerotic risk [J].

Bonetti, PO ;

Lerman, LO ;

Lerman, A .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (02) :168-175

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