Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host

被引：57

作者：

Maadani, Arash

Fox, Kristina A.

Mylonakis, Elftherios

Garsin, Danielle A.

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Microbiol & Mol Genet, Houston, TX 77030 USA

[2] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 05期

关键词：

D O I：

10.1128/IAI.01372-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enterococcus faecalis transposon insertion mutants were screened for attenuated killing of the nematode model host Caenorhabditis elegans. The genes disrupted in the attenuated mutants encode a variety of factors including transcriptional regulators, transporters, and damage control and repair systems. Five of nine mutants tested were attenuated in a mouse peritonitis model.

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页码：2634 / 2637

页数：4

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