Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome
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Juliana, Christine
[1
]
Fernandes-Alnemri, Teresa
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Fernandes-Alnemri, Teresa
[1
]
Wu, Jianghong
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Wu, Jianghong
[1
]
Datta, Pinaki
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Datta, Pinaki
[1
]
Solorzano, Leobaldo
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h-index: 0
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Thomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Solorzano, Leobaldo
[1
]
Yu, Je-Wook
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Thomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Yu, Je-Wook
[1
]
Meng, Rong
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h-index: 0
机构:
Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Meng, Rong
[2
]
Quong, Andrew A.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Quong, Andrew A.
[2
]
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Latz, Eicke
[3
,4
]
Scott, Charles P.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Scott, Charles P.
[1
]
Alnemri, Emad S.
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h-index: 0
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Thomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USAThomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
Alnemri, Emad S.
[1
]
机构:
[1] Thomas Jefferson Univ, Dept Biochem & Mol Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
[3] Univ Massachusetts, Dept Immunol & Infect Dis, Sch Med, Worcester, MA 01605 USA
Activation of the inflammasome generates the pro-inflammatory cytokines interleukin-1 beta and -18, which are important mediators of inflammation. Abnormal activation of the inflammasome leads to many inflammatory diseases, including gout, silicosis, neurodegeneration, and genetically inherited periodic fever syndromes. Therefore, identification of small molecule inhibitors that target the inflammasome is an important step toward developing effective therapeutics for the treatment of inflammation. Here, we show that the herbal NF-kappa B inhibitory compound parthenolide inhibits the activity of multiple inflammasomes in macrophages by directly inhibiting the protease activity of caspase-1. Additional investigations of other NF-kappa B inhibitors revealed that the synthetic I kappa B kinase-beta inhibitor Bay 11-7082 and structurally related vinyl sulfone compounds selectively inhibit NLRP3 inflammasome activity in macrophages independent of their inhibitory effect on NF-kappa B activity. In vitro assays of the effect of parthenolide and Bay 11-7082 on the ATPase activity of NLRP3 demonstrated that both compounds inhibit the ATPase activity of NLRP3, suggesting that the inhibitory effect of these compounds on inflammasome activity could be mediated in part through their effect on the ATPase activity of NLRP3. Our results thus elucidate the molecular mechanism for the therapeutic anti-inflammatory activity of parthenolide and identify vinyl sulfones as a new class of potential therapeutics that target the NLRP3 inflammasome.
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Univ Bonn, Dept Clin Chem & Pharmacol, D-5300 Bonn, Germany
Univ Munich, Div Clin Pharmacol, Dept Med, Munich, GermanyUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Bauernfeind, Franz G.
Horvath, Gabor
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Horvath, Gabor
Stutz, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Stutz, Andrea
Alnemri, Emad S.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Ctr Apoptosis Res, Kimmel Canc Inst, Philadelphia, PA 19107 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Alnemri, Emad S.
MacDonald, Kelly
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Pediat, Div Infect & Immunol Dis, Vancouver, BC V6T 1W5, Canada
British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, CanadaUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
MacDonald, Kelly
Speert, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Pediat, Div Infect & Immunol Dis, Vancouver, BC V6T 1W5, Canada
British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, CanadaUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Speert, David
Fernandes-Alnemri, Teresa
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Ctr Apoptosis Res, Kimmel Canc Inst, Philadelphia, PA 19107 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Fernandes-Alnemri, Teresa
Wu, Jianghong
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Ctr Apoptosis Res, Kimmel Canc Inst, Philadelphia, PA 19107 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Wu, Jianghong
Monks, Brian G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Monks, Brian G.
Fitzgerald, Katherine A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
Bergsbaken, Tessa
Fink, Susan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Mol & Cellular Biol, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
Fink, Susan L.
Cookson, Brad T.
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h-index: 0
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
Univ Washington, Dept Lab Med, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
机构:
Univ Iowa, Div Allergy & Immunol, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Cassel, Suzanne L.
Eisenbarth, Stephanie C.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Eisenbarth, Stephanie C.
Iyer, Shankar S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Infect Dis, Iowa City, IA 52242 USA
Univ Iowa, Inflammat Program, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Iyer, Shankar S.
Sadler, Jeffrey J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Infect Dis, Iowa City, IA 52242 USA
Univ Iowa, Inflammat Program, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Sadler, Jeffrey J.
Colegio, Oscar R.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06520 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Colegio, Oscar R.
Tephly, Linda A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Pulm & Crit Care Med, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Tephly, Linda A.
Carter, A. Brent
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h-index: 0
机构:
Univ Iowa, Div Pulm & Crit Care Med, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Carter, A. Brent
Rothman, Paul B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Rheumatol, Dept Internal Med, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Rothman, Paul B.
Flavell, Richard A.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Flavell, Richard A.
Sutterwala, Fayyaz S.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Univ Iowa, Div Infect Dis, Iowa City, IA 52242 USA
Univ Iowa, Inflammat Program, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
机构:
Univ Pittsburgh, Sch Med, Grad Program Immunol, Pittsburgh, PA 15213 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Chu, Jessica
Thomas, L. Michael
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Univ Pittsburgh, Sch Med, Grad Program Immunol, Pittsburgh, PA 15213 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Thomas, L. Michael
Watkins, Simon C.
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Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15213 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Watkins, Simon C.
Franchi, Luigi
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Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA
Univ Michigan, Ctr Comprehens Canc, Sch Med, Ann Arbor, MI 48109 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Franchi, Luigi
Nunez, Gabriel
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机构:
Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA
Univ Michigan, Ctr Comprehens Canc, Sch Med, Ann Arbor, MI 48109 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Nunez, Gabriel
Salter, Russell D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
机构:
Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Duncan, Joseph A.
Gao, Xi
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Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Gao, Xi
Huang, Max Tze-Han
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h-index: 0
机构:
Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Oral Biol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Huang, Max Tze-Han
O'Connor, Brian P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
O'Connor, Brian P.
Thomas, Christopher E.
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Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Thomas, Christopher E.
Willingham, Stephen B.
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Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Willingham, Stephen B.
Bergstralh, Daniel T.
论文数: 0引用数: 0
h-index: 0
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Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Bergstralh, Daniel T.
Jarvis, Gary A.
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机构:
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94121 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Jarvis, Gary A.
Sparling, P. Frederick
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机构:
Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Sparling, P. Frederick
Ting, Jenny P. -Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Oral Biol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Univ Bonn, Dept Clin Chem & Pharmacol, D-5300 Bonn, Germany
Univ Munich, Div Clin Pharmacol, Dept Med, Munich, GermanyUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Bauernfeind, Franz G.
Horvath, Gabor
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Horvath, Gabor
Stutz, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Stutz, Andrea
Alnemri, Emad S.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Ctr Apoptosis Res, Kimmel Canc Inst, Philadelphia, PA 19107 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Alnemri, Emad S.
MacDonald, Kelly
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Pediat, Div Infect & Immunol Dis, Vancouver, BC V6T 1W5, Canada
British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, CanadaUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
MacDonald, Kelly
Speert, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Pediat, Div Infect & Immunol Dis, Vancouver, BC V6T 1W5, Canada
British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, CanadaUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Speert, David
Fernandes-Alnemri, Teresa
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Ctr Apoptosis Res, Kimmel Canc Inst, Philadelphia, PA 19107 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Fernandes-Alnemri, Teresa
Wu, Jianghong
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Biochem & Mol Biol, Ctr Apoptosis Res, Kimmel Canc Inst, Philadelphia, PA 19107 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Wu, Jianghong
Monks, Brian G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
Monks, Brian G.
Fitzgerald, Katherine A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USAUniv Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA 01605 USA
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
Bergsbaken, Tessa
Fink, Susan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Mol & Cellular Biol, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
Fink, Susan L.
Cookson, Brad T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
Univ Washington, Dept Lab Med, Seattle, WA 98195 USAUniv Washington, Dept Microbiol, Seattle, WA 98195 USA
机构:
Univ Iowa, Div Allergy & Immunol, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Cassel, Suzanne L.
Eisenbarth, Stephanie C.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Eisenbarth, Stephanie C.
Iyer, Shankar S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Infect Dis, Iowa City, IA 52242 USA
Univ Iowa, Inflammat Program, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Iyer, Shankar S.
Sadler, Jeffrey J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Infect Dis, Iowa City, IA 52242 USA
Univ Iowa, Inflammat Program, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Sadler, Jeffrey J.
Colegio, Oscar R.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06520 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Colegio, Oscar R.
Tephly, Linda A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Pulm & Crit Care Med, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Tephly, Linda A.
Carter, A. Brent
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Pulm & Crit Care Med, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Carter, A. Brent
Rothman, Paul B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Rheumatol, Dept Internal Med, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Rothman, Paul B.
Flavell, Richard A.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Flavell, Richard A.
Sutterwala, Fayyaz S.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
Univ Iowa, Div Infect Dis, Iowa City, IA 52242 USA
Univ Iowa, Inflammat Program, Iowa City, IA 52242 USAYale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
机构:
Univ Pittsburgh, Sch Med, Grad Program Immunol, Pittsburgh, PA 15213 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Chu, Jessica
Thomas, L. Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Grad Program Immunol, Pittsburgh, PA 15213 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Thomas, L. Michael
Watkins, Simon C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15213 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Watkins, Simon C.
Franchi, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA
Univ Michigan, Ctr Comprehens Canc, Sch Med, Ann Arbor, MI 48109 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Franchi, Luigi
Nunez, Gabriel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA
Univ Michigan, Ctr Comprehens Canc, Sch Med, Ann Arbor, MI 48109 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
Nunez, Gabriel
Salter, Russell D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USAUniv Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA
机构:
Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Duncan, Joseph A.
Gao, Xi
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Gao, Xi
Huang, Max Tze-Han
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Oral Biol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Huang, Max Tze-Han
O'Connor, Brian P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
O'Connor, Brian P.
Thomas, Christopher E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Thomas, Christopher E.
Willingham, Stephen B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Willingham, Stephen B.
Bergstralh, Daniel T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Bergstralh, Daniel T.
Jarvis, Gary A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94121 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Jarvis, Gary A.
Sparling, P. Frederick
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
Sparling, P. Frederick
Ting, Jenny P. -Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Oral Biol, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA