Wittig reaction with partially protected sugar lactol derivatives. Preparation of highly cytotoxic goniofufurone analogues

被引：25

作者：

Popsavin, V

Grabez, S

Popsavin, M

Krstic, I

Kojic, V

Bogdanovic, G

Divjakovic, V

机构：

[1] Univ Novi Sad, Fac Sci, Dept Chem, YU-21000 Novi Sad, Serbia

[2] Inst Oncol Sremska Kamenica, YU-21204 Sremska Kamenica, Serbia

[3] Univ Novi Sad, Fac Sci, Dept Phys, YU-21000 Novi Sad, Serbia

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 51期

关键词：

goniofufurone analogues; furanolactones; cytotoxicity; D-xylose; D-lyxose; Wittig reaction; Michael ring closure;

D O I：

10.1016/j.tetlet.2004.10.122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to the dephenyl goniofufurone analogue 2 and the corresponding (3 S,4R)- stereo isomer 3 is reported. The resulting furanolactones 2 and 3 have shown a potent and selective in vitro cytotoxicity against certain human tumour cell lilies. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9409 / 9413

页数：5

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[2]

161::AID-PCA453&gt

[3]

3.0.CO

[4]

2-2