A novel exploratory method for visual recombination detection

被引：16

作者：

Strimmer, K

Forslund, K

Holland, B

Moulton, V

机构：

[1] Univ Munich, Dept Stat, D-80539 Munich, Germany

[2] Uppsala Univ, Linnaeus Ctr Bioinformat, S-755124 Uppsala, Sweden

[3] Allan Wilson Ctr Mol Ecol & Evolut, Palmerston North, New Zealand

来源：

GENOME BIOLOGY | 2003年 / 4卷 / 05期

关键词：

D O I：

10.1186/gb-2003-4-5-r33

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A versatile visual approach for detecting recombination and identifying recombination breakpoints within a sequence alignment is presented. The method is based on two novel diagrams - the highway plot and the occupancy plot - that graphically portray phylogenetic inhomogeneity along an alignment, and can be viewed as a synthesis of two widely used but unrelated methods: bootscanning and quartet-mapping. To illustrate the method, simulated data and HIV-1 and influenza A datasets are investigated.

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页数：12

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