DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae

被引：94

作者：

Foiani, M ^{[1
]}

Pellicioli, A ^{[1
]}

Lopes, M ^{[1
]}

Lucca, C ^{[1
]}

Ferrari, M ^{[1
]}

Liberi, G ^{[1
]}

Falconi, MM ^{[1
]}

Plevani, P ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Genet & Biol Microrganismi, I-20133 Milan, Italy

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2000年 / 451卷 / 1-2期

关键词：

budding yeast; cell cycle; checkpoints; DNA damage; DNA replication;

D O I：

10.1016/S0027-5107(00)00049-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In response to genotoxic agents and cell cycle blocks all eukaryotic cells activate a set of surveillance mechanisms called checkpoints. A subset of these mechanisms is represented by the DNA damage checkpoint, which is triggered by DNA lesions. The activation of this signal transduction pathway leads to a delay of cell cycle progression to prevent replication and segregation of damaged DNA molecules, and to induce transcription of several DNA repair genes. The yeast Saccharomyces cerevisiae has been invaluable in genetically dissecting the DNA damage checkpoint pathway and recent findings have provided new insights into the architecture of checkpoint protein complexes, in their order of function and in the mechanisms controlling DNA replication in response to DNA damage. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：187 / 196

页数：10

共 61 条

[11] Cell cycle checkpoints: Preventing an identity crisis [J].