Bone marrow abnormalities and early bone lesions in multiple myeloma and its precursor disease: a prospective study using functional and morphologic imaging

被引：24

作者：

Bhutani, Manisha ^{[1
,2
]}

Turkbey, Baris ^{[3
]}

Tan, Esther ^{[1
]}

Korde, Neha ^{[1
,4
]}

Kwok, Mary ^{[1
]}

Manasanch, Elisabet E. ^{[1
,5
]}

Tageja, Nishant ^{[1
]}

Mailankody, Sham ^{[1
]}

Roschewski, Mark ^{[1
]}

Mulquin, Marcia ^{[1
]}

Carpenter, Ashley ^{[1
]}

Lamping, Elizabeth ^{[1
]}

Minter, Alex R. ^{[1
]}

Weiss, Brendan M. ^{[1
,6
]}

Mena, Esther ^{[3
]}

Lindenberg, Liza ^{[3
]}

Calvo, Katherine R. ^{[7
]}

Maric, Irina ^{[7
]}

Usmani, Saad Z. ^{[2
]}

Choyke, Peter L. ^{[3
]}

Kurdziel, Karen ^{[3
]}

Landgren, Ola ^{[1
,4
]}

机构：

[1] NCI, Multiple Myeloma Sect, Lymphoid Malignancies Branch, CCR,NIH, Bethesda, MD 20892 USA

[2] Carolinas HealthCare Syst, Levine Canc Inst, Charlotte, NC USA

[3] NCI, Mol Imaging Program, CCR, NIH, Bethesda, MD 20892 USA

[4] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA

[5] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[6] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[7] NIH, Hematol Sect, DLM, CC, Bldg 10, Bethesda, MD 20892 USA

来源：

LEUKEMIA & LYMPHOMA | 2016年 / 57卷 / 05期

关键词：

MGUS; smoldering myeloma; multiple myeloma; functional imaging; DCE-MRI; NaF; FDG; PET; CT; UNDETERMINED SIGNIFICANCE MGUS; MONOCLONAL GAMMOPATHY; PROGNOSTIC-SIGNIFICANCE; FLOW-CYTOMETRY; FDG PET/CT; LONG-TERM; RISK; PROGRESSION; MANAGEMENT; F-18-FDG;

D O I：

10.3109/10428194.2015.1090572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The incidence and importance of bone marrow involvement and/or early bone lesions in multiple myeloma (MM) precursor diseases is largely unknown. This study prospectively compared the sensitivity of several imaging modalities in monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and MM. Thirty patients (10 each with MGUS, SMM and MM) were evaluated with skeletal survey, [F-18]FDG-PET/CT, [F-18]NaF-PET/CT and morphologic dynamic contrast enhanced (DCE)-MRI. An additional 16 SMM patients had skeletal surveys and FDG-PET/CT. Among MGUS patients, DCE-MRI found only one focal marrow abnormality; other evaluations were negative. Among 26 SMM patients, five (19%) were re-classified as MM based on lytic bone lesions on CT and six had unifocal or diffuse marrow abnormality. Among MM, marrow abnormalities were observed on FDG-PET/CT in 8/10 patients and on DCE-MRI in nine evaluable patients. Abnormal NaF uptake was observed only in MM patients with lytic lesions on CT, providing no additional clinical information.

引用

页码：1114 / 1121

页数：8

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