Association study between interleukin-1β gene (IL-1β) and schizophrenia

被引：14

作者：

Yang, HZ

Si, TM

Ling, YS

Ruan, Y

Han, YH

Wang, XL

Zhou, M

Zhang, DR

Zhang, HY

Kong, QM

Liu, C

Lia, XN

Yu, YQ

Liu, SZ

Shu, L

Ma, DL

Wei, J

Zhang, D ^{[1
]}

机构：

[1] Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China

[2] Jilin Univ, Ctr Genom Med, Changchun 130021, Peoples R China

[3] Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

来源：

LIFE SCIENCES | 2003年 / 72卷 / 26期

关键词：

schizophrenia; interleukin-1 beta (IL-1 beta); polymorphism; the transmission disequilibrium test (TDT);

D O I：

10.1016/S0024-3205(03)00248-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with the abnormal immune system, and cytokines may be important in schizophrenia. Among these cytokines, interleukin-1beta may play a role in the pathogenesis of the disease. In the present study, we investigated the genetic association between a TaqI polymorphism in interleukin-1beta gene (IL-1beta) and schizophrenia by restriction fragment length polymorphism, (RFLP) analysis among 132 Chinese families of Han descent. The transmission disequilibrium. test (TDT) did not demonstrate an allelic association with schizophrenia. Our results suggested that the TaqI polymorphism. in IL-1beta gene might not confer increased susceptibility for schizophrenia. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：3017 / 3021

页数：5

共 16 条

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