Insulin growth factor-I protects against excitotoxicity in the rat striatum

被引：11

作者：

Escartin, C

Boyer, F

Bemelmans, AP

Hantraye, P

Brouillet, E

机构：

[1] Serv Hosp Frederic Joliot, Dept Rech Med, Direct Sci Vivant, Unite Rech Associee 2210,CEA,CNRS, F-91401 Orsay, France

[2] Serv Hosp Frederic Joliot, Dept Rech Med, Direct Sci Vivant, Program ImaGene, F-91401 Orsay, France

[3] Hop Ophtalm Jules Gonin, Lab Oculogenet, CH-1004 Lausanne, Switzerland

来源：

NEUROREPORT | 2004年 / 15卷 / 14期

关键词：

excitotoxicity; Huntington's disease; IGF-1; neuroprotection; quinolinate; striatum;

D O I：

10.1097/00001756-200410050-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent findings demonstrated the neuroprotective effects of insulin-like growth factor 1 (IGF-1) in a cultured cell model of Huntington's disease. In the present study, we examined the potential neuroprotective effect of IGF-1 in vivo, in a rat model of Huntington's disease using the NMDA receptor agonist quinolinate. Continuous intracerebroventricular infusion of recombinant IGF-1 (0.25 mug/h for 2 days) in the rat brain, produced a significant 8-fold increase in striatal levels of the growth factor. Histological evaluation after intrastriatal injection of quinolinate showed that IGF-1 treatment significantly attenuated striatal degeneration. These results further support the therapeutic interest of IGF-1 in Huntington's disease.

引用

页码：2251 / 2254

页数：4

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