Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose

被引：31

作者：

Cox, LR

DeBoos, GA

Fullbrook, JJ

Percy, JM

Spencer, NS

Tolley, M

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

[2] Avecia Ltd, Manchester M9 8ZS, Lancs, England

[3] Univ Birmingham, Sch Chem Sci, Birmingham B15 2TT, W Midlands, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 03期

关键词：

D O I：

10.1021/ol0273553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route, of potential strategic importance, to a difluorosugar analogue has been developed. Key steps included a Stille coupling and a highly regio- and enantioselective dihydroxylation of a highly substituted diene. Protecting groups were chosen to enhance the reactivity of the disubstituted allylic fragment in the AD reaction and allow deprotection under orthogonal conditions.

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页码：337 / 339

页数：3

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