Vascular endothelial growth factor in colorectal cancer

被引：76

作者：

Guba, M ^{[1
]}

Seeliger, H ^{[1
]}

Kleespies, A ^{[1
]}

Jauch, KW ^{[1
]}

Bruns, C ^{[1
]}

机构：

[1] Univ Munich, Univ Clin Grosshadern, Dept Surg, D-81377 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 2004年 / 19卷 / 06期

关键词：

anti-angiogenic therapy; clinical trials targeting VEGF; colorectal cancer; colorectal cancer metastases; prognostic value; VEGF; VEGF pathway;

D O I：

10.1007/s00384-003-0576-y

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Angiogenesis plays an important role in colorectal cancer progression. Evidence from preclinical and clinical studies indicates that vascular endothelial growth factor (VEGF) is the predominant angiogenic factor in human colorectal cancer and is associated with formation of metastases and poor prognosis. Based on these results it was hypothesized that attacking one or more of the VEGF-mediated mechanisms may be promising in the treatment of colorectal cancer. Aims: This article reviews the role of VEGF in colon cancer and summarizes recent advances in the treatment of colorectal cancer by anti-VEGF strategies.

引用

页码：510 / 517

页数：8

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