Ob/ob mice as a model of delayed gastric emptying

被引：38

作者：

Asakawa, A

Inui, A

Ueno, N

Makino, S

Uemoto, M

Fujino, MA

Kasuga, M

机构：

[1] Kobe Univ, Grad Sch Med, Div Diabet Digest & Kidney Dis, Dept Clin Mol Med,Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Shionogi & Co Ltd, Anim Care Ctr, Shiga, Japan

[3] Kobe City Coll Nursing, Kobe, Hyogo, Japan

[4] Yamanashi Med Univ, Dept Internal Med 1, Yamanashi, Japan

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2003年 / 17卷 / 01期

关键词：

diabetic gastroparesis; ob/ob mice; gastric emptying;

D O I：

10.1016/S1056-8727(02)00198-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic gastroparesis is a well-recognized delay of gastric emptying in diabetic patients. We assessed the gastric emptying rate in ob/ob mice, a genetic model of obesity and diabetes. The basal gastric emptying rate in 22- to 27-week-old ob/ob mice was significantly lower than that in 10- to 11-week-old ob/ob mice (P<.01). Our results indicate that the ob/ob mice are a useful model not only of glucose intolerance but also of delayed gastric emptying as a diabetic complication. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：27 / 28

页数：2

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